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Lavigne picked up the Most Addictive Track trophy for "Girlfriend," as well as the Solo Artist of 2007 award – to which the 23-year-old screamed with delight to the packed auditorium: "I am so happy, this is an honor!"
Winehouse won the Artists' Choice award, the only honor decided by fellow musicians. The singer, who's appealing her recent pot charge, sheepishly accepted her award with a quiet "thanks" before walking off stage.
Later in the evening Winehouse sang her classic "Back to Black," but audience members noted the soul diva's lack of energy.
Rapper Snoop Dogg hosted the event, appearing on stage in a selection of outfits including traditional German lederhosen and a kilt. Performers included Mika (despite suffering from strep throat), Lavigne, My Chemical Romance, Babyshambles and the Foo Fighters.
Pete Doherty happily signed autographs for the fans before the show, despite telling reporters he felt "lethargic." But his performance later in the evening was anything but dreary. The rehabbing singer performed a crowd-pleasing rendition of "Delivery," reuniting with his band Babyshambles.
Earlier in the evening, Doherty denied any pre-show nerves, telling reporters: "It's second nature, it's what keeps me going really."
JOSH & FERGIE: ROCKED BY SCANDAL
Did he cheat with a stripper?
Married less than a year, the couple denies an Atlanta woman’s claims that she and Josh had a fling
Note that this week’s cover of PEOPLE may differ regionally
