The political power couple even got a special shout-out from frontman Bono, 55, during a performance of "Pride (In the Name of Love)," according to Billboard, when he thanked the former U.S. president for his efforts to broker peace in Ireland.
Bono also praised the Clintons' work fighting AIDS, according to CBS News, and later thanked Hillary for her advocacy for women.
Bruce Springsteen also attended the show, and was called up for two songs, "I Still Haven't Found What I'm Looking For" and a cover of "Stand By Me," according to Billboard.
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As Springsteen, 65, performed with the band Friday, the crowd reportedly erupted in cheers: "Bruuuuce!"
This isn't the first time they've all crossed paths.
In December, Springsteen subbed in for Bono at a concert for World AIDS Day while the Irish singer recovered from a bike accident; and Bill, 68, introduced the band, at Bono's request.