However, the actor's new look was no cause for alarm.
"This is what happens when you try to run up steps in the dark, with your arms full, wearing flip flops," Pitt said in a statement to PEOPLE. "Turns out if you then try to stop your forward momentum with your face, the result is road rash.
"Regardless, I wasn't going to miss the Autism Speaks benefit the night after – wonderful people and I was honored to be a part of this important event."
Jack Black acted as emcee for the event benefitting Autism Speaks, later auctioning off a Fender guiter signed by the performers from the event, all of whom have autism.
Pitt, 51, entered a bidding war for the guitar and ended up being the winner – surprising exactly no one – after offering up a whopping $23,000.
Also in attendance at the Pantages Theatre were celebrities such as Christina Applegate, Gary Cole and Amy Brenneman, and the night ended with all of the performers – Spencer Harte featuring Petra Haden, Nick Guzman and Matt Savage – singing Neil Young's "Rocking the Free World."
Reporting by MARY GREEN