While the former Chelsea Lately headliner promoted her new Netflix show Chelsea on Tuesday's Tonight Show, host Jimmy Fallon broached the topic of Handler's departure from the entertainment network.
"I want to know two things: One is, you have this show on E! You're the biggest name on E!" Fallon began – but Handler quickly cut him off: "Was I the biggest name on E!?"
Replied Fallon, "That wasn't a Kardashian? Yeah, I think so."
Handler, 41, quipped, "I didn't have a big enough ass to stay on that network."
The comedian then admitted that she left the network in hopes of finding happiness again.
"I don't want to take anything for granted, and I want to be in a good mood when I get to work every day," Handler began. "I was like, 'This place is so stupid.' I wanted to not be annoyed, you know what I mean? I wanted to be grateful that I had this life, that I get to do what I get to do ... I'm like, 'I don't want to be an ass.' "
Adding that, "I want to be happy. It was like I had my period the entire time."
Handler then asks Fallon, 41, "Have you ever had your period? It's not pretty."
To which the funnyman joked, "still waiting."
Chelsea premieres worldwide May 11 on Netflix. Chelsea marks Netflix’s first-ever talk show, with all new 30-minute episodes debuting on Wednesday, Thursday and Friday at 12:01am PST.