"I'm just grateful, super grateful," she told reporters at the Vacation premiere Monday night in Los Angeles.
Applegate, 43, chose to undergo a bilateral mastectomy in 2008 – although doctors only found cancer in one of her breasts – because she tested positive for the BRCA1 breast cancer gene and her mother had already battled breast cancer.
When asked Monday how her diagnosis changed her, Applegate said, "It changed me for a while, and now I'm just living life, living my life."
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Life now includes being a mom to daughter Sadie Grace, 4 ½, and she admitted that vacationing with a young child makes going away a bit more challenging.
"Oh my gosh, yeah, because it's not a vacation anymore," she said. "You know, you think you're relaxing, but you can't really relax when a 4 ½-year-old's needs have to be met."