The 84-year-old Bensenville, Illinois, resident was enjoying a cup of coffee when she heard noises coming from behind her home.
Jefferson went outside to investigate and found her neighbor's dog, Roxie, an Egyptian Pharoah Hound, surrounded by five coyotes.
According to Jefferson, one of the coyotes had Roxie by her head.
"He was huge. He was as big as any German Shepherd I've ever seen," Jefferson told NBC Chicago. "He turned around, looked at me, and Roxie got farther away from him."
As for how Jefferson scared the coyotes away?
"All I could remember, my son told me to yell, make a lot of noise if you see one, and that's what I did," she said.
Roxie was examined by a vet and is expected to make a full recovery, and her owner, Rich Parent, can't thank Jefferson enough.
"Here's this lady, pushing 85 years old, and she's my hero," he said.