To insiders, the famed Belmond Hotel Cipriani in Venice is known as "the Cip" (pronounced "chip").
This weekend, it may as well go by another name: George Clooney and Amal Alamuddin's Party Central.
A starry group of guests have already been spotted at the luxe resort as the couple's wedding festivities kick off, including Matt Damon, John Krasinski and more.
The bride's sister, Tala, enjoyed drinks with fellow revelers at the bar Thursday night, and Damon was seen nursing a Bellini with his wife Luciana at the pool.
A bar hall was set aside for a welcome celebration on Friday evening, and on Thursday gardeners freshened up the grounds with hundreds of white and pink Cyclamen blooms.
The groom has a history with the hotel: He's been a regular there for years while in town for the Venice Film Festival – and he's even helped create some of the libations on the hotel's Gabbiano Bar's cocktail menu.
The prestigious locale exudes Venetian flair: The 15th-century palazzo features local Murano glass and other handmade artifacts, antique furnishings and works from local artisans.
When they aren't tied up with the nuptials, guests are free to indulge in the resort's many upscale amenities, including the only pool in central Venice. And the hotel even offers private boat tours on the "Shirley" to explore neighboring islands, which are known for their artisanal culture of glassmaking and fishing.
With reporting by PETER MIKELBANK
PEOPLE.com Illustration By Debra Cartwright