"Oftentimes, I feel like an idiot talking to my own wife," he tells Esquire of the human rights lawyer for the magazine's May 2016 cover story.
Clooney, who wed Amal, 38, in 2014, has previously said that his wife is "the smart one" in their relationship, and is outspoken in his admiration of her.
"I've never been happier in a relationship by any stretch of the imagination," Clooney, 54, tells Esquire. "At 52. I found the love of my life and I'm really happy."
The Money Monster star also opens up to the magazine about another relationship in his life: his friendship with the commander in chief.
Clooney calls President Barack Obama "deeply funny," noting, "he gets the joke."
"He's called me a couple of times after I've gotten in an argument with somebody about him," the actor explains. "And he's like, 'What are you doing fighting with that guy?' That kind of stuff has been very funny."
The actor has also hit the court with POTUS, playing a basketball game together after a joint fundraiser in Los Angeles.
"He said, 'What are you doing tomorrow morning?' I go, 'What time?' He goes, '5:30. You wanna play some hoops?' And I go, 'Yeah,' " Clooney explains. "And he goes, 'All right, we'll set it up. You got any of your friends want to play?' "
He continues, "So I started writing my friends, going, 'You wanna play basketball with the president of the United States?' Now I have this picture of my buddy elbowing the President. It was really fun. He's a good basketball player."