The Democratic front-runner laughed off the idea when Today show host Matt Lauer asked her about it during an interview Friday.
"Oh my goodness! Matt, I know that they live in that world of fantasy and hope because they've got a mess on their hands on the Republican side," Clinton replied.
"That is not going to happen," she added of the possibility that she might ultimately be forced to take what Lauer called "some kind of political perp walk." "There is not even the remotest chance that it's going to happen."
Clinton dismissed the FBI investigation into her use of a private email server as a "security review" that had become politicized because of her involvement.
"I will tell you, sitting here in the Bronx, in this cafe, we're moving forward," she told Lauer. "The Republican's fondest wishes will not be fulfilled."