But when the inevitable question crept up during a Facebook Q&A session on Monday, Clinton made a surprising confession about the "hair and makeup tax" that even women like herself in "high-pressure" positions often have to pay.
"I know these questions can seem fluffy," Facebook user Libby Brittain wrote, "but as a young professional woman, I'd genuinely love to hear about how you manage getting ready each morning (especially during your time traveling as Secretary of State and now on the campaign trail) while staying focused on the 'real' work ahead of you that day."
"Amen, sister – you're preaching to the choir," Clinton responded. "It's a daily challenge. I do the best I can – and as you may have noticed, some days are better than others!"
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During the Facebook Q&A session, the first of her 2016 campaign, Clinton also vowed to make the student loan debt crisis a priority from "the first day I become president," and addressed how she would have responded to Black Lives Matter protestors who confronted her opponents Martin O'Malley and Bernie Sanders at a Netroots Nation convention on Saturday.
"Black lives matter," she said. "Everyone in this country should stand firmly behind that. We need to acknowledge some hard truths about race and justice in this country, and one of those hard truths is that that racial inequality is not merely a symptom of economic inequality."
Clinton also fired back at Senate Majority Leader Mitch McConnell, who reportedly accused her of playing "the gender card" in her campaign.
"Wow," she replied. "If that's what he said, Mitch McConnell really doesn't get it."
"There is a gender card being played in this campaign," she continued. "It's played every time Republicans vote against giving women equal pay, deny families access to affordable child care or family leave, refuse to let women make decisions about their health or have access to free contraception. These aren't just women's issues, they are economic issues that drive growth and affect all Americans. Anyone who doesn't get that doesn't understand what our lives are like."
For her part, Clinton seems to be using humor to take charge of the narrative about her appearance.
When asked whether she has a favorite pantsuit, she quipped: "I never met a pantsuit I didn't love."