Not only does the actress turn 47 on Thursday, but the weekend also marks the first Valentine's Day she and Justin Theroux will celebrate as husband and wife, as well as the release of Theroux's long-awaited new film, Zoolander 2, on Friday.
So what does she have in store for the big weekend?
Aniston admitted she might just let the milestone slide without much fanfare.
"I'm going to pass this year," she told PEOPLE last month, joking that it was "ridiculous" that another birthday was right around the corner.
"I might just quietly celebrate," she added.
Keeping with her low-key desires, the actress enjoyed a pre-birthday date with Theroux on Wednesday night in NYC. The two stepped out to see the Broadway show Hamilton at Richard Rodgers Theater.
It seems Theroux, 44, is onboard with a chill weekend at home. The happy couple hit the red carpet together on Tuesday for the Zoolander 2 premiere in NYC, where he admitted he doesn't have anything elaborate planned for Valentine's Day.
"I want to get into some sweatpants because I feel like I've been in a suit forever," he confessed to PEOPLE. "So we've done like, I don't know, six cities now. We're tired. So yeah, I'm going to get cozy and watch some HBO Go."
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But if this year is anything like her 46th birthday celebration, a night at home might not be in the cards. Aniston spent last year partying into the wee hours with friends at The Spare Room, a bar and gaming parlor at the Roosevelt Hotel in Los Angeles.
And even the actress couldn't help but hint at the potential for another blowout bash when she spoke to PEOPLE a few weeks ago.
"I do love any excuse for a party!" she said.