The actor has checked himself into a residential program for the treatment of substance abuse.
Last month, the 51-year-old star was charged with a DUI, after which he was briefly hospitalized for an unknown medical condition.
Following the incident, the beloved actor Tweeted to his fans: "Thanks to everyone for their love & support. I'm home & well."
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Stamos will star in a Netflix reboot of Full House, titled Fuller House, and his new Fox sitcom, Grandfathered, premieres this fall.