On Sunday, the Full House star, 52, was brought to tears at the TV Land Icon Awards while accepting the Timeless Icon statuette.
Stamos took the stage to dedicate his big moment to his late parents, saying, "I want to thank my parents. Boy, they would've loved this, Loretta and Bill ... they were really good people. They taught me to be kind and to be generous and to be loving to everyone that you meet on this journey."
While holding back tears, Stamos encouraged the audience to "appreciate every single moment you have on this planet because it's so damn precious. I'm going to treasure this moment, thank you."
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Stamos previous told PEOPLE on the red carpet about overcoming "rough patches," explaining that his family and friends have never left his corner.
"I've got to be honest," he told PEOPLE, "you don't really know you weren't doing so well until things are going really well. It's like, 'Wow, this is different.' I never knew I was doing so s-----."
"I've been through some rough patches and these people, my friends and family, have really stuck by me and cared about me and loved me," he said.