It all started on Friday when Rose, 31, spoke to New York's Power 105.1 about the Kardashian clan and gave her thoughts on rapper Tyga's alleged relationship with Jenner, 17. (He denied the romance on the same station Tuesday: "I'm not dating Kylie, I just want to get that out of the way. I want to be clear to everybody that I didn't leave my family to be with Kylie.")
Rose, who is close friends with Blac Chyna, the mother of Tyga's child, did not hold back.
"Kylie's a baby," she told The Breakfast Club. "She needs to go to bed at 7 o'clock and relax. It's ridiculous. Tyga should be ashamed of himself. That's how I feel, for sure. He has a beautiful woman and a baby that he left for a 16-year-old who just turned 17."
While rumors have been swirling about Tyga and Kylie ever since Tyga left Blac Chyna in the summer, Kardashian, 30, finally chose to set the record straight and fire back at Rose on Twitter.
" 'I was a stripper since I was 15 years old,' Amber Rose told Foxx," Kardashian Tweeted on Monday, quoting an old Amber Rose interview in which she divulged her past job. "Please don't worry about my sister who has a career and her s--- together at ONLY 17. People who live in glass houses shouldn't throw stones," she continued, adding: "Please stop talking about us in interviews mama. None of us talk about you."
Please stop talking about us in interviews mama. None of us talk about you. (3)— Khloé (@khloekardashian) February 16, 2015
When one follower Tweeted at Kardashian that Amber stripped to provide for her family, she responded in a way that indicated she was simply defending her sister: "Not mad she was a stripper. But don't say my sister should be in bed by 7."
“@jaileenieweenie: “to provide for her family wyd” not mad she was a stripper. But dont say my sister should be in bed by 7 when she wasn't— Khloé (@khloekardashian) February 16, 2015
"We get asked questions about people all the time and my sisters and I always take the high road and don't answer," Kardashian Tweeted. "Truth is we don't know these people. I don't know Amber so why would I comment on her. I'm not going to comment on someone I don't know. That's unfair."
these people. I don't know Amber so why would I comment on her. I'm not going to comment on someone I don't know. (2)— Khloé (@khloekardashian) February 16, 2015
That's unfair. We all hear things via social media or blogs but I would only want to comment on someone (3)— Khloé (@khloekardashian) February 16, 2015
if I actually knew them and or had my own personal history with them. I would think others would want the same respect.— Khloé (@khloekardashian) February 16, 2015
3 sides to EVERY story. His, hers and the truth. I'm not passing judgment but I wish others would do the same until they have FACTS.— Khloé (@khloekardashian) February 16, 2015
To her lengthy missive, Rose simply Tweeted back at Kardashian with the hashtag "#DontPanic," which is the title of a song by Kardashian's on-and-off boyfriend, French Montana. (Kardashian even starred in the video.)
Rose's feud with the Kardashians stems from her former relationship with Kanye West, whom she dated from 2008 to 2010.
"Kim is one of the main reasons me and Kanye are not together," Rose alleged to Star magazine in 2012. "She's a homewrecker! They were both cheating on me and Reggie [Bush] with each other."