The stars teamed up for a game of Charades on Wednesday's Tonight Show, playing against host Jimmy Fallon and special guest Norman Reedus.
Kardashian, 31, – who is 5' 10" – poked fun at DeVito's 5' 0" stature on Instagram, referencing one of the 71-year-old actor's most famous movies.
"Have you seen the movie Twins?!?! With Arnold Schwarzenegger and Danny DeVito?! I'm Arnold.... Danny plays himself," she hilariously captioned a photo of the pair standing side-by-side.
Between DeVito's interpretation of the song "Cheerleader" and Kardashian's best Pamela Anderson Baywatch impression, the duo barely edged out team Fallon-Reedus.
During her Tonight Show appearance, the estranged wife of Lamar Odom discussed her upcoming show Kocktails with Khloé, even revealing that her momager Kris Jenner made a tipsy cameo while drinking vodka straight.