The rapper released his newest song with Ryan Lewis, "White Privilege II," and it contains a series of diss lines aimed at musicians with a history of appropriating black culture.
"You've exploited and stolen the music, the moment," he raps at one point. "The magic, the passion, the fashion, you toy with / The culture was never yours to make better."
"You're Miley, you're Elvis, you're Iggy Azalea," the verse continues. "Fake and so plastic, you've heisted the magic/ You've taken the drums and the accent you rapped in/ You're branded 'hip-hop,' it's so fascist and backwards."
Azalea, who's frequently been held up as a poster child for cultural appropriation in the music industry, responded on Twitter.
"He shouldn't have spent the last 3 years having friendly convos and taking pictures together at events etc if those were his feelings," she wrote.
@lggysBae he shouldnt have spent the last 3 yrs having friendly convos and taking pictures together at events etc if those were his feelings— IGGY AZALEA (@IGGYAZALEA) January 22, 2016
"White Privilege II" features Chicago poet-vocalist Jamila Woods and clocks in at nine minutes long while touching on the Black Lives Matter movement and racial inequality in America. It will appear on Macklemore and Ryan Lewis' new album, This Unruly Mess I've Made, currently slated for a Feb. 26 release.