Margaret Cho Remembers Anna Nicole Smith's Last Days and Her 'Overwhelming Guilt' over Son's Death

04/14/2016 AT 05:50 PM EDT

Margaret Cho is paying tribute to her friend Anna Nicole Smith, who died in 2007 of a drug overdose.

Cho stars in a new music video called "Anna Nicole," from Cho's album American Myth and which tells the story of when the friends kissed in 2002's The Anna Nicole Show.

Cho also opened up about her friendship with Smith, whose death at 39 of a drug dose came shortly after her 20-year-old son Daniel died in 2006. Daniel passed away in Smith's hospital room just three days after she gave birth to her daughter Dannielynn. A pathologist later determined he died from a lethal combination of methadone, Zoloft and Lexapro, which had been prescribed to his mother.


"I think that her grief was overwhelming," Cho, 47, said on Sirius XM's Conversations with Maria Menounos. "So it has to do with some postpartum depression, some overwhelming guilt that her son had died. They both had an issue with prescription painkillers and different drugs like that. I don't know if there’s anybody that’s necessarily at fault. Of course, we're all guilty. Anybody that’s close to her is guilty, if anyone."



Margaret Cho Remembers Anna Nicole Smith's Last Days and Her 'Overwhelming Guilt' over Son's Death| People Picks, Margaret Cho

Margaret Cho (left) and Anna Nicole Smith

Santiago Felipe / Getty; Peter Kramer / Getty

Cho went on to describe the tragic scene of Smith learning of her son's death.

"I know it took them four hours to pry her off of his body. She wouldn't allow him to be buried, she just had to be next to him and near him," said Cho. "I couldn’t even picture it. I don't have a child, so I don’t know what that would feel like. Certainly people have to take that into consideration: the amazing torture and grief that she was experiencing anyway because of the loss of her son. And that with postpartum, too, it’s got to be hard."

In 2007 after Smith's death, Cho posted a touching tribute to her friend on her blog.

"I hope that she is happy now, where she is. It is easy to picture her there, riding the clouds, her young son at her side, a million miles above the paparazzi and the tabloids," wrote Cho.
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