"Know that it's not your fault and you're definitely not alone," Hargitay says in a new public-service announcement debuting Sunday during USA Network's SVU marathon.
"We stand with you," adds Biden, "because one is too many."
The video, produced for the NO MORE movement by Hargitay's Joyful Heart Foundation, is just the latest in a string of costarring roles for Biden and Hargitay, who share a commitment to combatting abuse of women.
"Joe Biden started the Violence Against Women Act 20 years ago and he was truly a visionary," Hargitay told David Letterman earlier this month. "Our missions are aligned and we have come together and done a bunch of work."
That included flying on Air Force Two – "a huge thrill for me," she says – to visit the National Domestic Violence Hotline headquarters in Texas last year.
"The crimes on Law & Order: SVU are sometimes fictionalized," Hargitay says in the PSA. "But sexual violence on college and university campuses is all-too real. And we cannot stand by while it happens."
"It's time," says Biden, "for all of us to speak up and end sexual assault."
Watch the video below: