Along with Deepak Chopra, Winfrey announced the release of their latest online 21-day meditation experience titled "Shedding the Weight: Mind, Body and Spirit."
"I have learned that weight can affect more than just our physical being, it takes on all kinds of different meaning in our lives," Winfrey, 62, said in a press release. "This meditation will help us recognize what we are really hungry for and help us move down the path to harmony within ourselves."
"Shedding the Weight: Mind, Body and Spirit," is the tenth meditation program from the pair, and is open for registration, which is free, on Thursday. The program itself begins March 21.
"I was inspired by Oprah's dramatic weight loss and her sensible approach to it," Chopra, 68, tells PEOPLE, "which was getting into balance at all levels."
The founder of the Chopra Center for Wellbeing was also inspired by his own weight loss of about 15 lbs. – a result of altering his sleeping habits and switching to an "almost vegan diet."
After journeying through the 20-minute audio mediations narrated by the pair, Chopra says users can expect to feel "lighter in body, mind and spirit."
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"Meditation decreases stress which is associated with high level hormones, cortisol and adrenaline. These hormones alter metabolism," he explains. "Cortisol adds belly fat, which in turn messes up the metabolism even more, starting a vicious cycle. At the same time, adrenaline overdrive causes inflammation in the body which interferes in the metabolic processes."
Winfrey has been open about her love for meditation in the past – whether she's making time for a 20-minute mediation or just a 5-minute period of silence.
"I give myself a chance just to be centered in prayerful thought, in alignment with something bigger than myself before I step out into the day," she said during a private Q&A session with Weight Watchers members last month. "I feel like I owe that to myself. And if I don't do that, then I don't feel like I'm good for the rest of the world."