Witherspoon, 38, shared a couple of Instagram pics on Friday from the set in New Orleans showing just how much she's bonded with the Modern Family star as they play a police officer and a prisoner on the run together.
"Happy Friday with @SofiaVergara," she captioned a pic of the two of them in costume, adding the hashtags #workwife #happywifehappylife.
And then, acting like a couple of preteens at a pajama party, Vergara – who split with fiancé Nick Loeb at the end of May, did her BFFs makeup.
"Thanks for the makeup @SofiaVergara Now can you do my hair?" the mom of three wrote.
Vergara, 41, shared a similar shot, captioning it, "Makeup emergency, NoLa Set! @RWitherspoon don’t panic!"
Witherspoon shared selfies with her new bestie a couple of weeks ago, so we're guessing it's just a matter of time till we see a shot of them braiding each other's hair.