The professional football player and Avagyan – who have been dating since 2011 – have a 14-month-old daughter, Briseis.
Bush, 29, is currently running back for the Detroit Lions. He famously dated Kim Kardashian for three years before they split in 2010. Armenian native Avagyan, 26, is a professional dancer.
Kardashian's stepbrother Brody Jenner attended the nuptials, sharing a photo of the newlyweds on his Instagram account.
Bush recently shared a sweet photo of Avagyan and their daughter.
The night before the nuptials, the couple went out to San Diego's FLUXX Nightclub with about 15 friends. The group kept things low-key, arriving a little before midnight and leaving around 1:20 a.m. after getting bottle service.
"Reggie was drinking Grey Goose vodka and Don Julio 1942 but seemed to be taking it pretty easy and not really partying," a source tells PEOPLE.
Reporting by MICHELLE TAN and MELODY CHIU