The reclusive reality star posted a photo of sister Kim Kardashian West's husband Kanye West gently kissing their 2-year-old daughter North's cheek.
Kardashian, 28, wiped his Instagram account clean earlier this summer before posting a #ThrowbackThursday picture of himself eating a sandwich in late July.
He's been appearing on Keeping Up with the Kardashians less and less after gaining weight over the past few years and battling depression.
He lives with sister Khloé Kardashian, who told Complex magazine that she's happy to be his support system.
"I have a big ass house and I wanted it so he could feel, like, comfortable," she explained. "He's going through a hard time now, and it's behind gates. With this crazy lifestyle you have to think of places where you can still have your freedom."