But off-screen, the actors who portrayed them had grown up together throughout the duration of the eight Harry Potter films – and not surprisingly, that made their much-anticipated kissing scene a little awkward.
"I never look back at that scene," Rupert Grint, who played Ron opposite Emma Watson's Hermione, told PEOPLE on Friday at Universal Orlando's three-day Celebration of Harry Potter event.
"I've known Emma since she was literally 9 years old and we had this very brother-sister relationship," explained the English actor, 27, whose new film Moonwalkers was released this month. "And it just felt very surreal. I have a memory of her face getting closer and closer. Like, 'Oh my God.' I can't really remember anything apart from that."
Asked if he would do anything differently in the famous scene, he replied, "One take was enough. It was such a huge moment and there was so much expectation. Quite a lot of pressure actually."
Grint is attending the fan-favorite Universal event, which takes place at the theme park's Wizarding World of Harry Potter, along with fellow Potter alums Matthew Lewis (a.k.a. "Hot Neville", Katie Leung (Cho Chang), Bonnie Wright (Ginny Weasley) and Evanna Lynch (Luna Lovegood).
Wright took to Instagram on Sunday to celebrate the Weasley family reunion.
"Family time," she captioned a picture of herself smiling alongside a funny-faced Grint.
Maybe the event will be moving the west coast soon – a massive Harry Potter-themed section is coming to Universal Studios in LA.