The 49-year-old TV chef took to Instagram this week to announce her first day back on set since being diagnosed with cancer.
"First day back on set – am shooting with @bobbyflay. Nice to be with my brother. #foodnetwork #bobbyflay," Lee captioned a photo of herself in a car, sporting a big grin.
The star guest judged a future episode of Beat Bobby Flay for the Food Network.
The smiling selfie comes one year after the celebrity chef was diagnosed with breast cancer.
On Wednesday, Lee also shared a candid photo of her pet bird Halo apparently trying to join her at work.
"As I leave for the set to shoot, Halo jumps in my bag and wants to go too! She doesn't realize that the only show she will probably ever be seen in is Halloween – and please, nobody tell her I shoot #Halloween next week!"
Lee had a double mastectomy last May and, due to complications, underwent surgery to treat a post-operative infection.
In September, the star announced her cancer-free status during an appearance on Good Morning America.
Around the same time, she wore a cleavage-flaunting pink Thierry Mugler dress to the Emmy Awards in an effort to send a message: "Women are not just their boobs," she told PEOPLE at the time.
The dedicated football fan also told PEOPLE last fall that she planned to have her reconstructive surgery after this year's Super Bowl.
Lee, who is New York Gov. Andrew Cuomo's long-term partner, has also used her battle with cancer to encourage early detection.
"We caught it early enough. What worries me is my sisters and my brothers – that they could get it and we don't catch it in time," she previously told PEOPLE.
"I cannot tell you enough how important it is to get your mammograms."