The comedian, 33, and his wife Lauren Miller, 34, have actively campaigned for further research and awareness of the neurodegenerative disease since Miller's mother, Adele, was diagnosed with early-onset Alzheimer's at the age of 55.
At Thursday night's charitable Unite4: Good and Variety's 3rd Annual Unite4: Humanity event, the couple was presented with the Unite2gether award for their work in organizing comedy shows to raise funds for families affected by Alzheimer's.
Before the Beverly Hills, California, event began, Rogen, who is known for his roles in Knocked Up and Pineapple Express, said it was important for him to use humor as a means to increase the public's knowledge of Alzheimer's.
"We can be true to our own passions and our own instincts of how to express ourselves and still help people and spread awareness and make people feel less alone," he told reporters. "That has actually been a very nice realization, because I never had anything I could talk honestly about that helped people before."
The pair was recognized for their comedic organization, Hilarity for Charity, that puts on performances to promote Alzheimer's awareness and raises funds for in-home care grants for families affected by the disease.
Since its inception, Rogen says the group has raised over $5 million for Alzheimer's research, support and care.
The couple's witty banter during their award acceptance speech garnered laughs from the star-studded audience, which included fellow actor honorees Matthew McConaughey, Morgan Freeman and Olivia Wilde.
"I'm going to tell my mom this is a SAG Award!" Rogen joked as he walked off stage.
In 2014, the This Is the End actor addressed a Senate committee about the disease, giving a moving testimony in favor of increased federal funding for Alzheimer's research.
Rogen and Miller ended their hilarious and heartwarming acceptance speech on Thursday with the comedian admitting that he "never saw himself being able to do any of this."
"But I found something that mattered to me, that I cared about," he continued. "And I did something about it."
Reporting by Scott Huver