The Democratic hopeful won seven states – Georgia, Virginia, Tennessee, Alabama, Arkansas, Massachusetts and Texas, as well as American Samoa – to Sen. Bernie Sanders' respectable four: Vermont, Oklahoma, Colorado and Minnesota. Clinton's early wins in Tennessee and Alabama were called by the Associated Press moments after the polls closed at 8 p.m.
Taking direct aim at GOP front-runner Donald Trump, who solidified his own lead on the Republican side with big Super Tuesday wins, Clinton said in her victory speech that the work of the country's next president "is not to make America great again."
"America never stopped being great. We have to make America whole. We have to to fill in what has been hollowed out. We have to make strong the broken places, restitch the bonds of trust and respect across our country."
Then, in a hoarse voice that showed the strain of months of nonstop campaigning, Clinton acknowledged, "It might be unusual ... for a presidential candidate to say this ... I believe what we need in America today is more love and kindness."
"Instead of building walls, we're going to break down barriers and build ladders of opportunity and empowerment so every American can live up to his or her full potential because then – and only then – can America live up to its full potential."
Clinton supporters took to Twitter to celebrate her win:
But the former secretary of state's winning night has not cleared her path. Trump pledged earlier on Tuesday to bedevil Clinton from the right with an unrelenting focus on the scandals she'd rather forget.
"We're going to be talking about those emails every moment of every day," he said.
And Sanders has vowed to continue his campaign until all 50 states have voted. He has the money – $41 million raised in the past month alone – to hang in for months.
Sanders promised supporters in Vermont Tuesday night that the race is far from over. "This is not a general election. It is not winner take all," he told the crowd. "If you get 52 percent, you get 48 percent, you roughly end up with the same amount of delegates in a state. By the end of tonight, we are going to win many hundreds of delegates."
"At the end of tonight, 15 states will have voted, 35 states remain. And let me assure you that we are going to take our fight for economic justice, for social justice, for environmental sanity, for a world of peace to everyone of those states."