The band's guitarist, The Edge (real name David Evans), became the first rock musician to perform in the Vatican City chapel, playing an acoustic set of his band's music with an Irish youth choir.
"When I was asked to perform in the Sistine Chapel I didn't know what to say, because usually there's 'this other guy' who sings," The Edge joked of Bono to the audience, according to NBC News. "So it took me at least, well, 30 seconds to agree to it."
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The 54-year-old was chosen to perform for the attendees of a conference on regenerative medicine because he's long served on the board of the Angiogenesis Foundation, according to NBC. The musician's daughter was diagnosed with leukemia in 2006.
The performance included songs like "Yahweh," "Ordinary World" and "Walk On."