From PEOPLE Magazine Click to enlarge
From Full House's Uncle Jesse to ER's hottest paramedic, Stamos, 43, has melted hearts with that charming grin. But what's a girl gotta do to win his affection? "I always find it real romantic if she leaves me a little note," he says.

THE RELUCTANT ROMEO
"I actually rescued a girl working in a store once. This weird, greasy guy was pressuring her for her number, and I pretended I was her boyfriend. She said, 'Thanks for saving me,' but I was too afraid to ask her out. I had to go back and ask the next day."

SET-UPS WELCOME
"It's pretty crystal clear I'm not going to meet The One at a bar somewhere, so I meet women mostly through friends. I even had a flight attendant try to fix me up. She pulled out a picture of her daughter and said, 'If you don't like her, I have another one.'"

THE UNCLE JESSE-OBSESSED NEED NOT APPLY
"Most of the girls in my dating range watched Full House. My filtering skills are pretty sharp. I get a clue right away when they start asking about my hair."