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EASTWICK
ABC, WEDNESDAYS 10 P.M.

LOOK WHO'S BACK
Rebecca Romijn (Ugly Betty) and Lindsay Price (Lipstick Jungle)

THE NEW SHOW
Jaime Ray Newman (left), Romijn and Price play three beguiling witches of Eastwick in a new take on the 1987 movie based on John Updike's 1984 novel. "It's going to take a lot to come to terms with the powers that we have," says Romijn, 36, who gains psychic abilities. "We're going to make mistakes." She's also adjusting to being on-set without twin girls Charlie and Dolly, born in December. "Jerry's on diaper duty," Romijn says of husband Jerry O'Connell. "He's Mr. Mom!"

COUGAR TOWN
ABC, WEDNESDAYS 9:30 P.M.

LOOK WHO'S BACK
Courteney Cox Arquette (Friends)

THE NEW SHOW
Divorced mom Jules (Cox) stalks the dating jungle once more with help and humor from her pride. "Being 40 is hard for women," says Cox, 45. "It would be really scary if I wasn't married and I had to get back out there again." From left: Ian Gomez, Busy Philipps, Cox, Christa Miller, Dan Byrd (front), Brian Van Holt, Josh Hopkins (back).

MODERN FAMILY
ABC, WEDNESDAYS 9 P.M.

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Ed O'Neill (Married ... with Children)

THE NEW SHOW
The last time O'Neill was called upon to play the patriarch of a sitcom family, he gave birth to Married's boorish Al Bundy, a role he inhabited for 11 seasons. But the Bundys were a typical, if dysfunctional, nuclear brood; in his new show, O'Neill's Jay is just one part of a broader, blended family—including a gay couple who have just adopted a child, a harried mom (Boston Legal's Julie Bowen) who orders her husband to punish their misbehaving son by shooting him with the boy's BB gun, and O'Neill's much younger new wife, played by Sofia Vergara. "I'm in a little over my head, I think, in this one," says O'Neill, 63, "and it's kind of fun to try to keep up."

HANK
ABC, WEDNESDAYS 8 P.M.

LOOK WHO'S BACK
Kelsey Grammer (Frasier)

THE NEW SHOW
He's been a fish-out-of-water (as Frasier Crane) and the big fish in a small pond (in Back to You), but in his latest sitcom, Grammer becomes Hank Pryor, a man content just to go fishing as a downsized New York City executive who relocates to a sleepy Virginia hamlet. "It's the opportunity to become a fully realized man," says Grammer, 54, of Hank. It's also a chance for Grammer to play another in his pantheon of urban sophisticates—this time opposite Melinda McGraw (below). "I'm well-spoken," he says with a laugh. "That's my trick!" But there's no big trick to bouncing back from his mild heart attack last summer. "I've always been a resilient guy, and I've been through difficulties before. So you get on track," he says. "I don't eat salt. That's about it."

COMMUNITY
NBC, THURSDAYS 9:30 P.M.

LOOK WHO'S BACK
Chevy Chase (Saturday Night Live)

THE NEW SHOW
Joel McHale (E!'s The Soup) plays Jeff Winger, a lawyer whose résumé fibs have gotten him bounced from the bar. Needing a real degree, he heads to community college, where he forms a motley study group with other smooth talkers like Chase's Pierce (above). "Joel reminds me of me when I was his age," says Chase, 65, who guested on Chuck but has never starred in a sitcom until now. "He's got the attitude and spice. In fact, I would have liked to have Joel's part—but I'm too old for it now!"

THE WANDA SYKES SHOW
FOX, SATURDAYS 11 P.M.

LOOK WHO'S BACK
Wanda Sykes (The New Adventures of Old Christine)

THE NEW SHOW
Sykes, 45, is keeping her Christine gig while hosting her own weekend talk show, but Paula Abdul's American Idol departure has given her an idea. "I'm gonna leave The Wanda Sykes Show and try to get her job," she quips, "because $5 million ain't too bad!"

THE MIDDLE
ABC, WEDNESDAYS 8:30 P.M.

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Patricia Heaton (Everybody Loves Raymond) and Neil Flynn (Scrubs)

THE NEW SHOW
Flynn and Heaton are Mike and Frankie Heck, a quarry manager and car saleswoman raising three kids in Indiana. "I relate to every single thing," says Heaton, 51, who has four boys of her own. "I grew up in Ohio, and midwestern roots are still really within me." So is the accent. "I had an acting teacher once that said, 'If you don't get rid of that Cleveland accent, you will never work,'" she says. "And that's all I've played, people from the Midwest. So it has worked for me!"

ACCIDENTALLY ON PURPOSE
CBS, MONDAYS 8:30 P.M.

LOOK WHO'S BACK
Jenna Elfman (Dharma & Greg)

THE NEW SHOW
A one-night stand leaves Elfman's Billie with a younger man she has to baby—and an actual baby on the way. Elfman, 37, hopes her character stays more fit during her pregnancy than the actress did with son Story, 2: "At a certain point, I stopped exercising and was just indulging—and I gained 57 lbs.!"

NCIS: LOS ANGELES
CBS, TUESDAYS 9 P.M.

LOOK WHO'S BACK
Chris O'Donnell (Head Cases) and LL Cool J (In the House)

THE NEW SHOW
What's the secret to playing special agents in the spiffy new NCIS spinoff? It's all about the look and the lingo. "I cut it once a week," says O'Donnell, 39, of his locks. "It cuts my grooming time down to five minutes!" As for the linguistics, "I speak a little of a lot of languages, and Arabic is one," says LL, 41. "I grabbed the CDs and Rosetta Stone'd it out!"