"The Holy Father is deceased this evening at 9:37 in his private apartment," papal spokesman Joaquin Navarro-Valls said in a statement. "Our beloved Holy Father John Paul II has returned to his home. Let us pray for him."
A Mass will be held in St. Peter's Square Sunday morning, according to reports.
The Holy Father had led the church for 26 years. In his radio speech on Saturday, President Bush called the Pope "a faithful servant of God and a champion of human dignity and freedom. ... He is an inspiration to us all."
At a Saturday morning press update, it was announced that the pope, though his words were barely audible and his breathing labored, had managed to say to those around him: "You come to me, and for this I thank you."
The pope's death came two weeks after his release from Rome's Gemelli hospital, where he had undergone surgery to have a breathing tube inserted in his throat after suffering larynx spasms.
As the Vatican announced on Friday, the Holy Father was suffering from a "urinary tract infection, septic shock and a cardio-circulatory collapse." (Septic shock affects the body's immune system, causing widespread inflammation and blood clots that hamper blood flow and the functions of the heart, lungs and kidneys.)
The pontiff had asked that he not be taken back to the hospital so that he could die in his own bed overlooking Vatican Square, and he was said to be mentally alert as his physical system broke down. It was also said that he declined painkillers.
On Friday, he had received the blessing for the dying after suffering heart failure and developing a high fever. That same day, the world's cardinals, who are responsible for selecting a successor, had been summoned to Rome.
According to the rules of the church, their secretive election procedure must begin within three weeks of the pope's passing.
Despite his long illness, the Pope, who was the third-longest serving pontiff in history, remained committed to continuing his work even through his final weeks. In his weekly address on Feb. 20, he said the call to "look after the flock" was "particularly alive" in him.
"Also in this hospital, in the middle of other sick people to whom my affectionate thoughts go out, I can continue to serve the church and the entire humanity," he said from Gemelli hospital.
The first non-Italian Pope in nearly five centuries and the first ever from Poland, he is considered by many to have been the most important leader of our time. As the often clandestine organizer of the nonviolent mass movement that freed Poland from Communist rule, John Paul II is credited with playing a major role in events that led to the fall of Soviet totalitarianism and the end of the Cold War.
"He'll go down in history as the greatest of our modern Popes," the Rev. Billy Graham once told Time magazine. "He's been the strong conscience of the whole Christian world."
From the first days of his reign in 1978, it was clear that John Paul II, born Karol Jozef Wojtyla in Wadowice, a small city 50 kilometers from Krakow, Poland, relished contact with his followers. The first pope ever to give a press conference, he would often extend impromptu breakfast invitations to officials visiting the Vatican. He shifted easily among seven languages and set out almost immediately on a series of travels that would eventually bring him to nearly every country during more than 100 trips. "This pope was revolutionary, because he didn't say, 'You have to learn my language,'" Jesuit theologian Rev. John Navone once told The New York Times. "He said, 'I'll learn your language.'"
Despite his global reach, John Paul, the second of two sons to Emilia, who died in 1929, and Karol Wojtyla, a non-commissioned army officer who died in 1941, was even more notable for his personal touch – the warmth of his personality and his uncanny ability to connect with individuals, from the stream of Presidents and prime ministers he met to churchgoers at parish churches to the young children he would embrace like a politician on the hustings.
He also displayed great fortitude. Though seriously wounded, John Paul survived a May 1981 assassination attempt by Turkish gunman Mehmet Ali Agca, who tried to kill him during a visit to St. Peter's Square in Rome. He later formally forgave him.