"When children have cancer, or when their parents or siblings have the disease, there are few places they can turn to for support," Spears – whose first child with husband Kevin Federline is due later this year – says in a statement.
"Gilda's Club is one of those places. I passionately believe in helping children in need, and so I am very happy to make this gift to help children learn they can cope with what can be a terrible and devastating experience for them," adds Spears, 23.
"We are very grateful to Britney Spears for her most generous gift," said Angelica Berrie, chairperson of Gilda's Club Worldwide. "It will improve the lives of hundreds of children who are living with cancer."