Mike Myers and Wife Split After 12 Years
"They remain committed and caring friends," publicist Ina Treciokas said in a statement.
Myers and Ruzan, a writer and actress, were married in May 1993. They have no children.
Myers, 42, formerly of "Saturday Night Live," starred in all three "Austin Powers" films.
His next project is Shrek 3, for which he will voice the popular green ogre.