And should Grey's star Patrick "Dr. McDreamy" Dempsey fail to send temperatures soaring at L.A.'s Shrine Auditorium, there's always host Conan O'Brien, who tells PEOPLE, "I'm gonna wear very, very tight trousers, like matador pants. That's gonna do a lot for women and a third of the men watching."
NBC will broadcast the ceremony live Sunday starting at 8 p.m. ET. The top nominees are the TNT miniseries Into the West, which garnered 16 nods, and HBO's miniseries Elizabeth I, starring Helen Mirren, which nabbed 13.
And while last year's big winners, ABC's Lost and Desperate Housewives, were shut out of the major races, the list of nominees features several shows that won't be back next season, including NBC's Will & Grace and The West Wing and HBO's Six Feet Under.
Sunday's ceremony will honor prolific producer Aaron Spelling, who died in June at 83 and whose decades of hits included The Mod Squad, The Love Boat, Starsky and Hutch, Dynasty and Beverly Hills, 90210. A tribute will feature cast members from his shows.