"I am convinced, completely convinced that there was nothing random about [the adoption]," the actress, 45, tells Redbook in its May issue. "She is the daughter I should have."
Months after applying to adopt a child in China, Ryan flew there to bring her baby daughter home to Los Angeles, PEOPLE reported in January 2006. Ryan initially named the girl Charlotte, but quickly realized that name didn't fit her and changed it.
"I thought she was Charlotte, and she's just not," Ryan said on The Oprah Winfrey Show in March of last year. "She's a Daisy. She's got the most open, beautiful, honest face you'll just ever see."
Of the adoption, Ryan tells Redbook, "I never felt like I was on a rescue mission or anything like that. I just really wanted a baby; I was on a mission to connect with somebody, and Daisy and I got to meet each other in this way at this time. We are so compatible."
Ryan also has a son who turns 15 this month, Jack Henry, whose father is her ex-husband, Dennis Quaid.
"This is the best time in my whole life," says Ryan, who is back on the screen in In the Land of Women after an absence of a few years. "I'm happy in my skin, I'm happy in my home, I'm happy in my career. I'm just very satisfied all around. I don't feel like I'm living anybody else's life, or anybody else's idea of what I should be doing, and it just feels very good."
Things were not so easy when she began her career. "When I first became famous, it was kind of traumatizing, actually. You just constantly feel like you're getting hit, you know?" she says. "I would say there's no real upside to fame. No really measurable one. There's money, but that doesn't necessarily come along with fame.
"People always say that they can get dinner reservations, but c'mon. You could always figure out some other way to dinner reservations."