DeGeneres's show won six trophies, including her fourth straight win for best talk show and third straight victory as best talk-show host.
"Portia, I still love you this year," DeGeneres joked onstage while accepting award, sending a shout-out to partner Portia de Rossi.
Speaking about her View competition, she added, "I really am shocked. ... I thought Rosie brought a lot of new viewers to daytime television and it was interesting."
And with that, she decided she wanted to follow Rosie, Elisabeth and company and become more controversial, the Associated Press reports.
"I know this might not be popular and I don't care because that's what I'm doing," she said. "I just want to say it – I think Bob Barker is a quitter."
Mark J. Terrill / AP
"I want to thank the television viewers across the country for inviting me into their homes for 50 years," he said, before ending the speech with his signature signoff. "And remember, help control the pet population. Have your pet spayed or neutered."
Backstage, when asked who could fill his shoes as host of Price Is Right, Barker floated Rosie O'Donnell as a possible successor.
"I believe they're going to have a meeting with Rosie," Barker told reporters backstage, according to AP.
"She knows the show. There's no doubt in my mind she could do the show," he said. "Now, whether they want a lady host, I don't know. I've never heard that discussed. As far as I know, they've only auditioned men."