For best dramatic series, besides Grey's, the nominees are Boston Legal, Heroes, House and The Sopranos, which ended its series run with 15 nominations, including two for stars James Gandolfini and Edie Falco.
In the race for outstanding comedy series, the nominees are Entourage, The Office, 30 Rock, Two and a Half Men and Ugly Betty, which followed right behind The Sopranos in total nominations, picking up 11.
The top nominee is HBO's made-for-TV movie Bury My Heart at Wounded Knee, with 17. (See the complete list at Emmys.org.)
Meanwhile, surprises included Lost getting shut out for outstanding drama, though supporting actors Terry O'Quinn and Michael Emerson received nominations. Also shut out of the actor categories was critically acclaimed freshman drama Friday Night Lights.
KEN BABOLCSAY / iPOL / GLOBE
The Drama Nominees...The other contenders for leading male actor in a drama series are Hugh Laurie in House, Denis Leary in Rescue Me, James Spader in Boston Legal and Kiefer Sutherland in 24.
Leading actresses in a drama, in addition to Falco, are Patricia Arquette (Medium), Minnie Driver (The Riches), Sally Field (Brothers and Sisters), Mariska Hargitay (Law & Order: Special Victims Unit) and Kyra Sedgwick (The Closer).
As for the Comedies...Lead actress nominees are Tina Fey (30 Rock), America Ferrara (Ugly Betty), Julia Louis-Dreyfus (The New Adventures of Old Christine), Felicity Huffman (Desperate Housewives) and Mary-Louise Parker for Weeds.
Among the men, it's Alec Baldwin (30 Rock), Steve Carell (The Office), Ricky Gervais (Extras), Tony Shalhoub (Monk) and the newly engaged Charlie Sheen (Two and Half Men).
The Emmys will be broadcast live on FOX Sunday, Sept. 16.
Keep checking back to People.com for reactions from all the top nominees!
Reporting by MONICA RIZZO