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Swank, 33, is likely to end up with a short 'do, as Winfrey reportedly cut some nine inches off her hair to donate it to Pantene Beautiful Lengths, an initiative dedicated to supporting and encouraging women who have lost their hair during cancer treatment.
"It's taken months to get to this moment," Winfrey says. "It involves a two-time Academy Award winner, a sharp object, and me."
"I've been growing it for the last six months to donate my hair," Swank says. "I've been taking a lot of vitamins and taking really good care of it, knowing that it would go to a woman in need."
Also as part of Oprah's Great American Haircut show, 100 viewers will get 100 makeovers over 48 hours.
JOSH & FERGIE: ROCKED BY SCANDAL
Did he cheat with a stripper?
Married less than a year, the couple denies an Atlanta woman’s claims that she and Josh had a fling
Note that this week’s cover of PEOPLE may differ regionally
