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Shireen Ritchie spoke on Britain's GMTV program, which was highlighting the plight of orphaned children.
Madonna is in the process of adopting a Malawian boy, David Banda, after his father placed him in an orphanage in October 2006 following the death of his mother.
Interviewer Fiona Phillips asked: "You have probably one of the most famous adopted little grandsons in the whole world now. How's that all working out?"
"It's working out very well," Ritchie replied. "They're wonderful and loving parents and he's a very lucky little boy."
JOSH & FERGIE: ROCKED BY SCANDAL
Did he cheat with a stripper?
Married less than a year, the couple denies an Atlanta woman’s claims that she and Josh had a fling
Note that this week’s cover of PEOPLE may differ regionally
