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He succumbed to a fatal hemorrhage early Tuesday morning at Charing Cross Hospital in Hammersmith, west London, his rep tells PEOPLE. Minghella had an operation last week for a growth in his neck, which "seemed to have gone well."
Minghella's other movies included 1999's The Talented Mr. Ripley, which made a star out of Jude Law, and 2003's Cold Mountain, which won an Oscar for its Supporting Actress Renée Zellweger.
His most recent movie was The No. 1 Ladies' Detective Agency, which he recently finished filming in Botswana, reports CNN.
Minghella was married to Hong Kong-born choreographer Carolyn Choa.
Since 2003, he was chairman of the British Film Institute.
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