The couple, their four children, two nannies and three bodyguards arrived in a private Gulfstream jet at Nice and drove to nearby St Jean Cap Ferrat. According to local sources, they're staying at Microsoft co-founder Paul Allen's historic Villa Maryland.
The Florentine-styled villa with pool overlooks the peninsula's small yacht harbor and commands an unparalleled view of the Mediterranean. The couple previously borrowed the villa for a one-week stay during their 2006 French break preceding the birth of daughter Shiloh.
The villa has year-round staffing of 12 and is often used by Allen for celebrity-packed dinners during the Cannes Film Festival and Monaco Grand Prix weekend.
Pitt and Jolie are expected to remain in St Jean Cap Ferrat through the Cannes Film Festival, May 14-25. Pregnancy permitting, Jolie is scheduled to walk the red carpet for two films, Kung Fu Panda on May 15 and Clint Eastwood's The Changeling on May 20.