The couple – who are hunkering down in St Jean Cap Ferrat at the historic villa owned by Microsoft co-founder Paul Allen – appeared to be house hunting, sources say, exploring four possible properties.
The next day, the expectant parents and their entire brood (daughters Zahara, 3, and Shiloh, 1, and sons Maddox, 6, and Pax, 4) stayed closer to home, visiting Bono's waterfront home at Eze, France, about 15 minutes from Allen's luxury compound.
While their weekend may sound glamorous, one local source insists that, when it comes to daily life inside the villa, they're just like any other family on vacation.
"They're doing everything you and I might be doing," said the source. "Eating, taking naps and swimming in the pool."
Later this month, the pregnant Jolie is scheduled to walk the red carpet at the Cannes Film Festival for two films, Kung Fu Panda and The Changeling.
Reporting by DANA KENNEDY and PETER MIKELBANK