Last Friday, the couple – who first stepped out in public in April – headed for a little R&R at Casa Aramara, the sprawling beachfront home of Girls Gone Wild mogul Joe Francis, in Punta Mita, Mexico.
The house is a hot spot for celebs: Demi Moore celebrated her 45th birthday there in November, and Aniston has visited the pad with former beau (and costar) Vince Vaughn and platonic pal Orlando Bloom.
This time around, the couple and a group of friends spent the weekend lounging on the house's beachfront patio, enjoying their Mexican getaway.
"Jen spent time laying out on the loungers on the patio. John was always around, standing by her, making sure she was comfortable," says an onlooker.
Before departing for Mexico, Aniston and Mayer were also spotted discreetly holding hands June 12 while double dating with Aniston’s BFF and former Friends costar Courteney Cox and her husband David Arquette.
Reporting by JENNIFER GARCIA