"I don't know why women do Botox," the freckled redhead tells Britain's Observer Magazine. "It doesn't make them look younger, it just makes them look like they had work done."
She adds: "You are not going to look the same as you did at 25. What are you going to do about it?"
Admittedly, she says, "It's hard for actresses. Our faces get to be blown up 50 feet wide, and you see stuff that otherwise you wouldn't. People freak out."
Pointing to lines between her eyebrows, she says, "The other day I noticed these. I never used to have lines here ... I can get very distracted by it."
Not that there are barriers to age, she professes. No stranger to onscreen nudity, as those who saw her in Robert Altman's Short Cuts can attest, Moore believes there should be no maximum age limit to baring all.
"I try not to worry about it or think that there's any limit," she says. "But as for actually being comfortable in my own skin, I don't think anybody is ... it's not possible to feel good about yourself at all times."
Happy HomelifeThe actress lives a satisfied life with her film-director husband Bart Freundlich, 38, and their two children Cal, 10 and Liv, 5.
"It's so nice to have a boy and a girl. I am lucky, lucky, lucky," she says. "I always tell my little girl that I can remember lying in the bathtub when I was pregnant, and I say I wished and I wished for a girl and got her."
After giving birth, Moore took her time going back to work. "My friend Ellen Barkin gave me the best piece of advice. She said: 'Don't go back to work for as long as you possibly can. Sit on the couch with the remote in one hand and the baby in the other.' "