People Exclusive

VIDEO: Sneak Peek at Meg Ryan's The Women

08/07/2008 at 12:20 PM EDT

Mary Haines is just expecting a routine nail appointment. What she gets, though, is some disturbing news about her husband!

So goes the action in PEOPLE's exclusive clip from The Women, starring Meg Ryan (as Haines) and Debi Mazar. The film, which also stars Annette Benning, Eva Mendes and Jada Pinkett-Smith, follows a group of friends as they all begin questioning their own relationships after Ryan's character discovers her husband's infidelity. The Women is due in theaters Sept. 12.
– Brian Orloff