Christina Applegate Returns to Samantha Who? Set
09/15/2008 AT 01:45 PM EDT
The actress underwent a double mastectomy in July, after being diagnosed with breast cancer. The surgery was a success, and Applegate, 36, says she's cancer free.
Applegate subsequently appeared on the Sept. 5 Stand Up to Cancer telethon, and is expected to present at the Primetime Emmy Awards on Sept. 21. She is also nominated as lead actress in a comedy series.
Samantha Who?'s second season premieres on Oct. 13.
Reporting by JULIE JORDAN and LISA INGRASSIA
See Christina's 'Most Beautiful' photo spread!
See more celebs who've bravely battled cancer