Christina Applegate Returns to Samantha Who? Set

By Brian Orloff

09/15/2008 at 01:45 PM EDT

Christina Applegate has returned to work, her rep confirms to PEOPLE, as filming on her ABC comedy Samantha Who? resumed Monday in Los Angeles.

The actress underwent a double mastectomy in July, after being diagnosed with breast cancer. The surgery was a success, and Applegate, 36, says she's cancer free.

Applegate subsequently appeared on the Sept. 5 Stand Up to Cancer telethon, and is expected to present at the Primetime Emmy Awards on Sept. 21. She is also nominated as lead actress in a comedy series.

Samantha Who?'s second season premieres on Oct. 13.

• Reporting by JULIE JORDAN and LISA INGRASSIA

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