House returns with a typically puzzling case involving a struggling career woman who suffers a psychotic break during her boss's big presentation. Her symptoms play hide-and-seek and all but stick out a tongue to blow a raspberry at House's new team. But a good deal more is going on for the grumbling wreck that is House (Emmy-nominated Hugh Laurie): Dr. Wilson (Robert Sean Leonard) wants to leave. He's grieving for his lover, Amber, whose death last season was inadvertently caused by House. House is saddled with a potential sense of loss and guilt too, but it's mostly for his colleague, not poor Amber.
House has a heart, we know by now, but it beats in its own perverse way.