Strong Medicine

updated 11/10/2008 AT 01:00 AM EST

originally published 11/10/2008 AT 01:00 AM EST

ACROSS

1 Arli$$ starred Robert ___ and 15 Across

5 Newscaster Rather

8 Actor Giamatti (Sideways costar of 15 Across)

12 The Mediterranean for example (2 wds.)

13 "Hold on Tight" rock group

14 Multinational money unit

15 A star of Grey's Anatomy (2 wds.)

17 Seann William Scott comedy Road ___

18 Actress Skye

19 The Black Eyed ___

20 Adam Sandler's Mr. ___

22 Raising the ___ with Mark-Paul Gosselaar

23 One ___ Move

24 Body of Lies star Crowe

28 Actress Ortiz on Ugly Betty

29 Actor ___ Def of Be Kind Rewind

30 ___ Dawn Chong

31 Patrick ___ (Grey's Anatomy costar of 15 Across)

34 The Duchess's Knightley

36 Whitney Houston's birth month (abbr.)

37 James Earl ___

38 ___ After Reading

40 Benny Goodman standard "___ Winds"

41 Actor Ruffalo of Zodiac and Reservation Road

42 ___ Moore (15 Across's Blindness costar)

46 Glenn Close thriller Jagged ___

47 Alleged psychic Geller

48 Privy to (2 wds.)

49 ___-do-well

50 Bernadette Peters' "___ Whiz"

51 Actor Jared ___ of Panic Room

DOWN

1 "'Til There ___ You"

2 "Born in the ___"

3 Female fowl

4 Judi Dench film ___ in Lavender

5 Cain, Jones and Martin

6 ___ vera (sunburn remedy)

7 Japanese dance drama

8 Krause and O'Toole

9 Invisible emanation

10 A God in Ruins author Leon ___

11 Cut off

16 John Ford western Two ___ Together

19 ___ de deux (Baryshnikov dance, often)

20 Eric ___ (Grey's Anatomy costar of 15 Across)

21 Actor Jack ___ of westerns

22 Marilyn Monroe movie ___ Stop

23 Trendy game or fashion, e.g.

24 "Mean Woman Blues" singer Orbison

25 A Great Lake

26 Drummer Ulrich of Metallica

27 Actress Thompson

29 The Women star Ryan

32 Sarah Jessica ___

33 Under the Tuscan ___ features 15 Across

34 Former statesman Annan of the U.N.

35 Involve

37 Changeling with Angelina ___

38 __ farewell (said goodbye)

39 Coax

40 Three Dog Night's "___ as I'm Sittin' Here"

41 Drama series Mad ___

42 Glenn Miller hit "The Little Brown ___"

43 Arizona-to-Wyoming direction

44 ___ Another Teen Movie

45 Rock producer Brian ___

For more Puzzlers, go to www.people.com/puzzler

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