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The little girl, whose name has not been released, is the first for the 46-year-old actress and her husband, Ian Gomez, E! Online reports.
The couple adopted the toddler, who is less that 5 years old, several months ago.
"They are going public now to bring attention to National Adoption Month and the 500,000 children in foster care," according to a statement from Vardalos's rep. "Of these children, 129,000 are 'legally free' for adoption and waiting for a family."
The couple urge people interested in adoption to visit, AdoptUsKids.org.
Up next for Vardalos are roles in My Life in Ruins and I Hate Valentine's Day, which she wrote and directed.
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