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Arquette, 40, cited irreconcilable differences, and is seeking sole legal and physical custody of their daughter Harlow, 5, with visitation for Jane, 39.
The couple were married in May 2006, but the exact date of separation is "to be determined," according to the Superior Court papers. The pair had met through friends around 2001.
Arquette isn't seeking spousal support, and she's requesting the court deny him any.
The star of TV's Medium, whose sister is Rosanna Arquette and brother is David Arquette [husband of Courteney Cox Arquette], also starred in the offbeat movies like True Romance and Lost Highway.
Arquette has a son, Enzo, 19, with musician Paul Rossi.
JOSH & FERGIE: ROCKED BY SCANDAL
Did he cheat with a stripper?
Married less than a year, the couple denies an Atlanta woman’s claims that she and Josh had a fling
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